Article
Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.
Circulation research - 3 Feb 2023
Aherrahrou Rédouane, Lue Dillon, Perry R Noah, Aberra Yonathan Tamrat, Khan Mohammad Daud, Soh Joon Yuhl, Örd Tiit, Singha Prosanta, Yang Qianyi, Gilani Huda, Benavente Ernest Diez, Wong Doris, Hinkle Jameson, Ma Lijiang, Sheynkman Gloria M, den Ruijter Hester M, Miller Clint L, Björkegren Johan L M, Kaikkonen Minna U, Civelek Mete
Abstract excerpt
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these loci are in noncoding regions and are predicted to regulate gene expression. Given that vascular smooth muscle cells (SMCs) play critical roles in the development and progression of CAD, we aimed to...
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