Article

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

2024-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Hypoxia rapidly alters gene expression to allow cellular adaptation to challenging conditions and support tumour growth. Hypoxia also affects the chromatin structure by modifications of histones and DNA methylation. Glioblastoma (GBM) is an aggressive, deadly primary brain tumour for which there is no effective treatment. The tumour microenvironment of GBM is highly heterogeneous, with infiltrat...

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Literature Corpus work: dc3aa64a-9c9a-58c5-be74-d3e519abf527
DOI: 10.1101/2024.09.12.612769

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