Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.

doi:10.1186/s13073-024-01321-8

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Article

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.

Genome medicine - 2 Apr 2024

Yabo Yahaya A, Moreno-Sanchez Pilar M, Pires-Afonso Yolanda, Kaoma Tony, Nosirov Bakhtiyor, Scafidi Andrea, Ermini Luca, Lipsa Anuja, Oudin Anaïs, Kyriakis Dimitrios, Grzyb Kamil, Poovathingal Suresh K, Poli Aurélie, Muller Arnaud, Toth Reka, Klink Barbara, Berchem Guy, Berthold Christophe, Hertel Frank, Mittelbronn Michel, Heiland Dieter H, Skupin Alexander, Nazarov Petr V, Niclou Simone P, Michelucci Alessandro, Golebiewska Anna

Abstract excerpt

BACKGROUND: A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microglia and peripheral monocyte-derived macrophages, play critical pro-tumoral roles. However, it is unclear whether recruited myeloid cells are phenotypically and functionally...

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Identifiers

PMID: 38566128
DOI: 10.1186/s13073-024-01321-8
PMCID: PMC10988817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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