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Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

2023-03-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microglia and peripheral monocyte-derived macrophages, play critical pro-tumoral roles. However, it is unclear whether recruited myeloid cells are phenotyp...

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Literature Corpus work
5583ea7e-f21f-53aa-86c4-6af2903c3134
DOI
10.1101/2023.03.05.531162
Open publication

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Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenograftsDOI 10.1101/2023.03.05.531162
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