Article
Programs, origins and immunomodulatory functions of myeloid cells in glioma.
Nature - 1 Apr 2025
Miller Tyler E, El Farran Chadi A, Couturier Charles P, Chen Zeyu, D'Antonio Joshua P, Verga Julia, Villanueva Martin A, Gonzalez Castro L Nicolas, Tong Yuzhou Evelyn, Saadi Tariq Al, Chiocca Andrew N, Zhang Yuanyuan, Fischer David S, Heiland Dieter Henrik, Guerriero Jennifer L, Petrecca Kevin, Suva Mario L, Shalek Alex K, Bernstein Bradley E
Abstract excerpt
Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined1. Here we systematically investigate these phenotypes by integrating single-cell RNA sequencing, chromatin accessibility, spatial transcriptomics and glioma organoid explant systems. We discovered four immunomodulatory expression...
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