Article

Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas

2026-06-03

Abstract excerpt

<h4>Background</h4> While hypoxia is a well-established driver of glioblastoma progression, its role in IDH-mutant gliomas, characterized by localized hypoxic microenvironments rather than overt necrosis, remains poorly understood. Here, we investigate how hypoxia and microenvironmental-adaptations shape cellular heterogeneity and transcriptional plasticity in these tumors. <h4>Methods</h4> We integrated bulk, s...

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Literature Corpus work: 79349673-2cd9-5a38-af61-b07c1631cd0a
DOI: 10.64898/2026.05.31.729105

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