Article
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Cancer cell - 10 Jul 2017
Wang Qianghu, Hu Baoli, Hu Xin, Kim Hoon, Squatrito Massimo, Scarpace Lisa, deCarvalho Ana C, Lyu Sali, Li Pengping, Li Yan, Barthel Floris, Cho Hee Jin, Lin Yu-Hsi, Satani Nikunj, Martinez-Ledesma Emmanuel, Zheng Siyuan, Chang Edward, Sauvé Charles-Etienne Gabriel, Olar Adriana, Lan Zheng D, Finocchiaro Gaetano, Phillips Joanna J, Berger Mitchel S, Gabrusiewicz Konrad R, Wang Guocan, Eskilsson Eskil, Hu Jian, Mikkelsen Tom, DePinho Ronald A, Muller Florian, Heimberger Amy B, Sulman Erik P, Nam Do-Hyun, Verhaak Roel G W
Abstract excerpt
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T...
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