Article

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

2021-07-12

Abstract excerpt

Glioma microenvironment contains numerous myeloid cells, including brain-resident microglia and recruited monocytes and macrophages (Mo/Mφ). When studied collectively, these cells presented pro-tumor effects. Yet, little is known about the differences among these myeloid populations. Using single-cell sequencing analysis, we studied the phenotypic characteristics, spatial variances, and dynamic changes of these re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57e18f29-5a7a-54b1-9c01-3bcb6d2fc13a
DOI: 10.1101/2021.07.11.451874

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brainDOI 10.1101/2021.07.11.451874Read

A Microglial Subset at the Tumor-Stroma Interface of GliomaSemantic proximity Read

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironmentSemantic proximity Read

Macrophages/Microglia in the Glioblastoma Tumor MicroenvironmentSemantic proximity Read

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.Semantic proximity Read

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophagesSemantic proximity Read

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenograftsSemantic proximity Read

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.Semantic proximity Read

Epithelial-mesenchymal transition is the main way in which glioma-associated microglia/macrophages promote glioma progressionSemantic proximity Read

Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastomaSemantic proximity Read

The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia.Semantic proximity Read

In Search for Reliable Markers of Glioma-Induced Polarization of MicrogliaSemantic proximity Read