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Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival

17 May 2024

Abstract excerpt

Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of phenotypic and activation states. We now have limited knowledge of the tumor microenvironment (TME) determinants that influence the localization and the functions of the diverse myeloid cell populations in GBM. Here, we have utilized orthogonal imaging mass cytometry with single-cell and spatial transcriptomic approaches to...

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PMID: 38758780
DOI: 10.1126/sciadv.adj3301

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