Article

The NSL complex promotes neural development by preventing R-loop induced replication stress

2025-08-27

Abstract excerpt

<h4>Summary</h4> Early neuronal development relies on the proliferation of neural progenitor cells, making this developmental stage particularly vulnerable to DNA replication impediments. Here, we identify a non-canonical role for the non-specific lethal (NSL) complex in safeguarding DNA replication during neurodevelopment. The NSL complex, which acetylates histone 4 at gene promoters and is mutated in Koolen-de...

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Literature Corpus work: dbfb472f-07a4-5d6d-904d-f770a56e7153
DOI: 10.1101/2025.08.22.671281

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