Article

Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes

2024-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, which must withstand decades of DNA damage without replicating. This lack of knowledge limits the efficiency and precision of genome editing in clinically rele...

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Literature Corpus work: 46a5f665-63af-5255-8769-41427ebaf9a2
DOI: 10.1101/2024.06.25.600517

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