Article

Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21

2026-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cel...

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Literature Corpus work: 0ae952b9-fcf7-5754-8480-2f1906808487
DOI: 10.64898/2026.06.01.729170

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