Article

Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons

2020-03-26

Abstract excerpt

Neurons are the longest-living cells in our bodies, becoming post-mitotic in early development upon terminal differentiation. Their lack of DNA replication makes them reliant on DNA repair mechanisms to maintain genome fidelity. These repair mechanisms decline with age, potentially giving rise to genomic dysfunction that may influence cognitive decline and neurodegenerative diseases. Despite this challenge, our kn...

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Literature Corpus work: 53eeb2e7-04f1-512d-9e05-2f9ae78a0923
DOI: 10.1101/2020.03.25.008490

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