Article

The Integrator complex prevents premature neuronal differentiation through global control of transcription elongation

2024-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Transcription pause-release constitutes a key step in the regulation of gene expression. Pathogenic variants in various pausing regulators have been identified in neurodevelopmental disorders, but how transcription pause-release regulates neural development remains largely unknown. Here we show that a patient-specific in-frame deletion in Integrator subunit 8 (INTS8) that prevents association of...

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Literature Corpus work: 133a3637-0b73-54d4-9437-7fd4a8f75a4b
DOI: 10.1101/2024.11.26.625369

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