Article

Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes

2023-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Common variants associated with schizophrenia are concentrated in non-coding regulatory sequences, but their precise target genes are context-dependent and impacted by cell-type-specific three-dimensional spatial chromatin organization. Here, we map long-range chromosomal conformations in isogenic human dopaminergic, GABAergic, and glutamatergic neurons to track developmentally programmed shifts...

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Literature Corpus work: b8fb45d1-8430-5f68-b746-59cfae715b93
DOI: 10.1101/2023.07.17.549339

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