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Article

A NPAS4-NuA4 complex couples synaptic activity to DNA repair.

Nature - 1 Feb 2023

Pollina Elizabeth A, Gilliam Daniel T, Landau Andrew T, Lin Cindy, Pajarillo Naomi, Davis Christopher P, Harmin David A, Yap Ee-Lynn, Vogel Ian R, Griffith Eric C, Nagy M Aurel, Ling Emi, Duffy Erin E, Sabatini Bernardo L, Weitz Charles J, Greenberg Michael E

Abstract excerpt

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic neurons1-5. Whether neurons have acquired specialized genome protection mechanisms that enable them to withstand decades of potentially damaging stimuli during periods of heightened activity is unknown. Here we identify an activity-dependent DNA repair...

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Identifiers

PMID: 36792830
DOI: 10.1038/s41586-023-05711-7
PMCID: PMC9946837

Genes

NPAS4

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