Article

R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription

2023-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Here, we construct genome-scale maps for R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced single strand of DNA, in the proliferative and differentiated zones of the human prenatal brain. We show that R-loops are abundant in the progenitor-rich germinal matrix, with preferential formation at promoters slated for upregulated expression at later stages o...

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Literature Corpus work: 8cf29a14-9ce3-5ef4-b29d-c02e1bb4e441
DOI: 10.1101/2023.07.18.549494

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