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Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.

Trends in genetics : TIG - 1 Apr 2021

Bellelli Roberto, Boulton Simon J

Abstract excerpt

Human development and tissue homeostasis depend on the regulated control of cellular proliferation and differentiation. DNA replication is essential to couple genome duplication and cell division with the establishment and maintenance of cellular differentiation programs. In eukaryotes, DNA replication is performed by a large machine known as the 'replisome,' which is strictly regulated in a cell cycle-dependent...

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Identifiers

PMID: 33041047
DOI: 10.1016/j.tig.2020.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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