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Article

Structural basis for Porcupine inhibition

2025-05-19

Abstract excerpt

Wnt signalling is essential for embryonic development and tissue homeostasis, and its dysregulation is associated with multiple types of cancer. Porcupine (PORCN), an endoplasmic reticulum (ER)-resident membrane-bound O-acyltransferase, catalyses the palmitoylation of all 19 human Wnts—a critical modification required for their secretion and activity. This central role makes PORCN an attractive therapeutic target...

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Literature Corpus work
dbdd99fe-dd61-5d23-90a2-95e734c45fde
DOI
10.1101/2025.05.19.654776
Open publication

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Structural basis for Porcupine inhibitionDOI 10.1101/2025.05.19.654776
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