Article

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

2020-01-08

Abstract excerpt

Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family 1 . It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage 2 . SOAT1 is a target to treat several human diseases 3 . However, its structure and mechanism remain elusive since its discovery. Here...

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Literature Corpus work: cac97bb0-e1c2-5e11-95ec-dd76691e0707
DOI: 10.1101/2020.01.07.897124

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