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Article

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

PloS one - 1 Jan 2012

Covey Tracy M, Kaur Simran, Tan Ong Tina, Proffitt Kyle D, Wu Yonghui, Tan Patrick, Virshup David M

Abstract excerpt

Porcupine (PORCN) is a membrane-bound O-acyl transferase that is required for the palmitoylation of Wnt proteins, and that is essential in diverse Wnt pathways for Wnt-Wntless (WLS) binding, Wnt secretion, and Wnt signaling activity. We tested if PORCN was required for the proliferation of transformed cells. Knockdown of PORCN by multiple independent siRNAs results in a cell growth defect in a subset of...

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Topics

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Share to Acyltransferases
Share to Cell Proliferation
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Intracellular Signaling Peptides and Proteins

Share to Neoplasms, Glandular and Epithelial

Share to Receptors, G-Protein-Coupled

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22509316
DOI: 10.1371/journal.pone.0034532
PMCID: PMC3324524

Genes

PORCN
WLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.PMID 22509316Read ↗

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary CancerSemantic proximity Read ↗

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Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibitionSemantic proximity Read ↗

Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.Semantic proximity Read ↗

Structural model of PORCN illuminates disease-associated variants and drug binding sitesSemantic proximity Read ↗

Palmitoylation of proteins in cancer.Semantic proximity Read ↗

Fatty acylation of Wnt proteins.Semantic proximity Read ↗

Structural basis for Porcupine inhibitionSemantic proximity Read ↗

Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axisSemantic proximity Read ↗

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.Semantic proximity Read ↗

Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.Semantic proximity Read ↗

Deletion of mouse <i>Porcn</i> blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndromeSemantic proximity Read ↗

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