Article

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

2022-09-15

Abstract excerpt

Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O -acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain developmental disorders, and reduced expression is linked to fatty liver disease. Further, increased MBOAT7 expression is linked to hepatocellular and renal cancers. The mechani...

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Literature Corpus work: 1695d28f-343d-53d0-bfdb-f407df97574f
DOI: 10.1101/2022.09.15.508141

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