Article
Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition
28 Mar 2022
Abstract excerpt
Gastrointestinal cancers are responsible for more cancer deaths than any other system of the body. This review summarises how Wnt pathway dysregulation contributes to the development of the most common gastrointestinal cancers, with a particular focus on the nature and frequency of upstream pathway aberrations. Tumors with upstream aberrations maintain a dependency on the presence of functional Wnt ligand, and...
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