Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fatty acylation of Wnt proteins.

Nature chemical biology - 1 Feb 2016

Nile Aaron H, Hannoush Rami N

Abstract excerpt

Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. Once secreted, Wnts signal through the cell surface via receptor binding on Wnt-receiving cells, a mechanism that is prevalent in stem cell and cancer biology. Important to both Wnt secretion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Acylation
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids, Unsaturated

Share to Molecular Structure

Share to Protein Isoforms

Share to Wnt Proteins

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 26784846
DOI: 10.1038/nchembio.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fatty acylation of Wnt proteins.PMID 26784846Read ↗

Structural model of PORCN illuminates disease-associated variants and drug binding sitesSemantic proximity Read ↗

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary CancerSemantic proximity Read ↗

Structural basis for Porcupine inhibitionSemantic proximity Read ↗

Palmitoylation of proteins in cancer.Semantic proximity Read ↗

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.Semantic proximity Read ↗

Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.Semantic proximity Read ↗

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.Semantic proximity Read ↗

Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.Semantic proximity Read ↗

Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibitionSemantic proximity Read ↗

Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.Semantic proximity Read ↗

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.Semantic proximity Read ↗

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.