Article
Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.
European journal of pharmacology - 15 Apr 2023
Yang Qihong, Qin Tong, An Tao, Wu Hongna, Xu Gang, Xiang Jin, Lei Kangfan, Zhang Shaohua, Xia Jie, Su Guifeng, Wang Dan, Xue Minggao, Kong Lingmei, Zhang Wenxuan, Wu Song, Li Yan
Abstract excerpt
Wnt/β-catenin signaling pathway is a classical and crucial oncogenic pathway in many carcinomas, and Porcupine (PORCN) is an O-acyltransferase, which is indispensable and highly specific for catalyzing palmitoylation of Wnt ligands and facilitating their secretion and biofunction. Targeting PORCN provides a promising approach to specifically cure Wnt-driven cancers from the root. In this study, we designed series...
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