Article

Inhibiting Wnt Secretion Reduces High Bone Mass Caused by Sost Deficiency or Point Mutations in Lrp5

2023-01-10

Abstract excerpt

<title>Abstract</title> <p>Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signaling components, which increase the pathway's activity in the skeleton, cause high bone mass in human patients and mouse models. Increased bone mass is often accompanied by severe headaches from increased intracranial pressure, which can lead to fatality and loss of...

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Literature Corpus work: 0437de67-d29d-5f7d-a0f7-2611d79e9d19
DOI: 10.21203/rs.3.rs-2436798/v1

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