Article

Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity

2022-06-11

Abstract excerpt

<h4>ABSTRACT</h4> The paralogous oncogenic transcriptional coactivators YAP and TAZ are the distal effectors of the Hippo signaling pathway, which play a critical role in cell proliferation, survival and cell fate specification. The core kinase cascade of the Hippo signaling pathway phosphorylates YAP/TAZ and restrict its activity by promoting cytoplasmic sequestration and degradation. Unphosphorylated YAP/TAZ tr...

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Literature Corpus work: 0d320114-049e-5482-a2a0-0a8569ddbb62
DOI: 10.1101/2022.06.09.495565

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