Article

Structural model of PORCN illuminates disease-associated variants and drug binding sites

2021-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Wnt signaling is essential for normal development and is a therapeutic target in cancer. The enzyme PORCN, or porcupine, is a membrane-bound O-acyltransferase (MBOAT) that is required for the post-translational modification of all Wnts, adding an essential mono-unsaturated palmitoleic acid to a serine on the tip of Wnt hairpin 2. Inherited mutations in PORCN cause focal dermal hypoplasia, and th...

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Literature Corpus work: 5b606565-5a66-5caf-83ef-76e5062c8bd3
DOI: 10.1101/2021.07.19.452875

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