Article

Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

2020-07-12

Abstract excerpt

<h4>ABSTRACT</h4> We establish a genome-wide map of DNA methylation quantitative trait locus (mQTL) effects in CD4 + T cells isolated from multiple sclerosis (MS) patients. Utilizing this map in a colocalization analysis, we identify 19 loci where the same haplotype drives both MS susceptibility and local ( cis -) DNA methylation. We also identify two distant ( trans -) mQTL effects of MS susceptibility loci:...

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Literature Corpus work: dbabadeb-9469-5eb7-8c55-95a06f222c21
DOI: 10.1101/2020.07.11.198721

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