Article

DNA methylation signatures of Multiple Sclerosis occur independently of genetic risk and are primarily attributed to B cells and monocytes

2023-02-14

Abstract excerpt

<title>Abstract</title> <p>Multiple sclerosis is a complex autoimmune disease that causes neuronal demyelination and debilitating physical and cognitive symptoms. Epigenetic factors can mediate genetic and environmental effects on disease risk. Here we profiled blood-based DNA methylation in 583 MS cases and 643 healthy controls representing 3 independent study groups. An epigenome-wide association study was perf...

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Literature Corpus work: 670ee8fe-9d9a-59aa-a659-707e01bfa72c
DOI: 10.21203/rs.3.rs-2570500/v1

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