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Article

Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.

Nature communications - 6 Dec 2021

Roostaei Tina, Klein Hans-Ulrich, Ma Yiyi, Felsky Daniel, Kivisäkk Pia, Connor Sarah M, Kroshilina Alexandra, Yung Christina, Kaskow Belinda J, Shao Xiaorong, Rhead Brooke, Ordovás José M, Absher Devin M, Arnett Donna K, Liu Jia, Patsopoulos Nikolaos, Barcellos Lisa F, Weiner Howard L, De Jager Philip L

Abstract excerpt

Identifying the effects of genetic variation on the epigenome in disease-relevant cell types can help advance our understanding of the first molecular contributions of genetic susceptibility to disease onset. Here, we establish a genome-wide map of DNA methylation quantitative trait loci in CD4+ T-cells isolated from multiple sclerosis patients. Utilizing this map in a colocalization analysis, we identify 19 loci...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

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Source

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Identifiers

PMID: 34873174
DOI: 10.1038/s41467-021-27427-w
PMCID: PMC8648735

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