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DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis

7 May 2019

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with a modest concordance rate in monozygotic twins, which strongly argues for involvement of epigenetic factors. We observe highly similar peripheral blood mononuclear cell-based methylomes in 45 MS-discordant monozygotic twins. Nevertheless, we identify seven MS-associated differentially methylated positions (DMPs)...

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PMID: 31064978
DOI: 10.1038/s41467-019-09984-3

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