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Article

Utilising multi-large omics data to elucidate biological mechanisms within multiple sclerosis genetic susceptibility loci.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2021

Zhou Yuan, Cuellar-Partida Gabriel, Simpson Yap Steve, Lin Xin, Claflin Suzi, Burdon Kathryn, Charlesworth Jac, Taylor Bruce

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have succeeded in identifying over 200 susceptibility loci for multiple sclerosis (MS). However, the potential functional variants and the mechanisms by which these loci affect MS risk remain largely unexplained. OBJECTIVES: We used summary data-based Mendelian randomisation to prioritise risk genes and infer potential biological mechanisms for MS risk loci....

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Identifiers

PMID: 33870794
DOI: 10.1177/13524585211004422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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