Article
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells.
Life science alliance - 1 Jul 2020
Gresle Melissa M, Jordan Margaret A, Stankovich Jim, Spelman Tim, Johnson Laura J, Laverick Louise, Hamlett Alison, Smith Letitia D, Jokubaitis Vilija G, Baker Josephine, Haartsen Jodi, Taylor Bruce, Charlesworth Jac, Bahlo Melanie, Speed Terence P, Brown Matthew A, Field Judith, Baxter Alan G, Butzkueven Helmut
Abstract excerpt
At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk. A key function that could mediate SNP-encoded MS risk is their regulatory effects on gene expression. We performed microarrays using RNA extracted from purified immune cell types from 73 untreated MS cases and 97 healthy controls and then performed Cis expression quantitative trait loci mapping studies using...
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