Article

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling

2020-09-02

Abstract excerpt

G protein-coupled receptors (GPCRs) allow cells to respond to chemical and sensory stimuli through generation of second messengers, such as cyclic AMP (cAMP), which in turn mediate a myriad of processes, including cell survival, proliferation, and differentiation. In order to gain deeper insights into the complex biology and physiology of these key cellular pathways, it is critical to be able to globally map the m...

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Literature Corpus work: db9e3c14-6093-54b4-b1fe-a1dbca099471
DOI: 10.1101/2020.09.02.279679

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