Article
Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System
2017-06-20
Abstract excerpt
G-protein coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes, and detects a wide array of physiological cues in the human body. We describe a new molecular device that couples CRISPR-Cas9 programmed genome regulation to natural and synthetic extracellular signals via GPCRs. The design of our synthetic device, named CRISPR ChaCha, displays superior performance over...
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Identifiers and source
- Literature Corpus work
- 637b2714-6da0-5328-adc5-231027b90d78
- DOI
- 10.1101/152496