Article
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.
Scientific reports - 29 May 2020
Lukasheva Viktoriya, Devost Dominic, Le Gouill Christian, Namkung Yoon, Martin Ryan D, Longpré Jean-Michel, Amraei Mohammad, Shinjo Yuji, Hogue Mireille, Lagacé Monique, Breton Billy, Aoki Junken, Tanny Jason C, Laporte Stéphane A, Pineyro Graciela, Inoue Asuka, Bouvier Michel, Hébert Terence E
Abstract excerpt
A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established pathways. Here, using an array of sixteen validated BRET-based biosensors, we analyzed the ability of seven different β-adrenergic ligands to engage five distinct signalling pathways downstream of the β1-adrenergic receptor (β1AR). In addition to generating...
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