Article

Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1

2025-04-23

Abstract excerpt

Levels of receptors on the cell surface control the sensitivity of immune cells, which is central to achieving effective responses while avoiding inflammatory diseases. The chemoattractant receptor FPR1 activates strong chemotactic and cytotoxic responses in neutrophils. While its precise regulation is critical for appropriate responses, the mechanisms controlling its cell surface levels remain unclear. Here, we i...

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Literature Corpus work: 2ee362d5-66ad-56f6-8009-8226f2b263f2
DOI: 10.1101/2025.04.21.649864

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