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Article

A new era in functional genomics screens.

Nature reviews. Genetics - 1 Feb 2022

Przybyla Laralynne, Gilbert Luke A

Abstract excerpt

The past 25 years of genomics research first revealed which genes are encoded by the human genome and then a detailed catalogue of human genome variation associated with many diseases. Despite this, the function of many genes and gene regulatory elements remains poorly characterized, which limits our ability to apply these insights to human disease. The advent of new CRISPR functional genomics tools allows for...

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PMID: 34545248
DOI: 10.1038/s41576-021-00409-w

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