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A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

2024-02-28

Abstract excerpt

Understanding the complex interplay between gene expression and neuronal activity is crucial for unraveling the molecular mechanisms underlying cognitive function and neurological disorders. Here, we developed pooled screens for neuronal activity, using CRISPR interference (CRISPRi) and the fluorescent calcium integrator CaMPARI2. Using this screening method, we evaluated 1343 genes for their effect on excitabilit...

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Literature Corpus work
df0440dc-6002-5e77-82d2-7b116c47c2c5
DOI
10.1101/2024.02.28.582546
Open publication

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A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal ActivityDOI 10.1101/2024.02.28.582546
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