Article

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

2018-08-03

Abstract excerpt

<h4>SUMMARY</h4> Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve the design of genetically reprogrammed cell-based therapies. However, large-scale CRISPR screens have been challenging in primary human cells. We developed a new method, s gRNA l entiviral i nfection with C as9 pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2539de4b-cf13-5d38-9382-56c0b8272d3c
DOI: 10.1101/384776

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune FunctionDOI 10.1101/384776Read

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune FunctionSemantic proximity Read

CRISPR activation and interference screens decode stimulation responses in primary human T cellsSemantic proximity Read

CRISPR–Cas9 applications in T cells and adoptive T cell therapiesSemantic proximity Read

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screensSemantic proximity Read

CRISPR activation and interference screens in primary human T cells decode cytokine regulationSemantic proximity Read

Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapySemantic proximity Read

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieusSemantic proximity Read

A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host FactorsSemantic proximity Read

Precision CRISPR annotation of the functional enhancer landscape in primary human T cellsSemantic proximity Read

Functional Interrogation of Primary Human T Cells via CRISPR Genetic EditingSemantic proximity Read

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens.Semantic proximity Read

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumorsSemantic proximity Read