Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors

29 Dec 2022

Abstract excerpt

SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor dependencies may present an attractive strategy for anti-viral therapy. In this study, we performed genome wide CRISPR knockout screens in Vero E6 cells and four human cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to CRISPR and Genetic Engineering
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36597481
DOI: 10.1016/j.heliyon.2022.e12744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factorsPMID 36597481Read ↗

Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; <i>ACE2</i>Semantic proximity Read ↗

Systematic Genome-Scale Identification of Host Factors for SARS-CoV-2 Infection Across Models Yields a Core Single Gene Dependency; <i>Ace2</i>Semantic proximity Read ↗

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronavirusesSemantic proximity Read ↗

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsSemantic proximity Read ↗

Genome-scale CRISPR screens identify host factors that promote human coronavirus infectionSemantic proximity Read ↗

Genome-scale CRISPR Screens Identify Host Factors that Promote Human Coronavirus InfectionSemantic proximity Read ↗

CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2Semantic proximity Read ↗

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 InfectionSemantic proximity Read ↗

Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2Semantic proximity Read ↗

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concernSemantic proximity Read ↗

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infectionSemantic proximity Read ↗

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.