Article

When more is less: Dual phosphorylation protects signaling off-state against overexpression

2018-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Kinases in signaling pathways are commonly activated by multisite phosphorylation. For example, the mitogen-activated protein kinase Erk is activated by its kinase Mek by two consecutive phosphorylations within its activation loop. In this article, we use kinetic models to study how the activation of Erk is coupled to its abundance. Intuitively, Erk activity should rise with increasing amounts o...

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Literature Corpus work: db0e1139-da27-5e90-a134-87dbb031d356
DOI: 10.1101/295899

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