Article

Multi range ERK responses shape the proliferative trajectory of single cells following oncogene induced senescence

2022-10-07

Abstract excerpt

<h4>SUMMARY</h4> Oncogene-induced senescence (OIS) is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing OIS display phenotypic heterogeneity, with some cells senescing and others remaining proliferative. The causes of the heterogeneity remain poorly understood. We studied the sources of heterogeneity in the responses of human epith...

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Literature Corpus work: 3a06cd9f-983f-5d5f-a5e6-c327e7ca320b
DOI: 10.1101/2022.10.06.511142

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