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Article

Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations.

Current biology : CB - 9 Mar 2020

Yeung Eyan, McFann Sarah, Marsh Lewis, Dufresne Emilie, Filippi Sarah, Harrington Heather A, Shvartsman Stanislav Y, Wühr Martin

Abstract excerpt

Multisite protein phosphorylation plays a critical role in cell regulation [1-3]. It is widely appreciated that the functional capabilities of multisite phosphorylation depend on the order and kinetics of phosphorylation steps, but kinetic aspects of multisite phosphorylation remain poorly understood [4-6]. Here, we focus on what appears to be the simplest scenario, when a protein is phosphorylated on only two...

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Identifiers

PMID: 32059766
DOI: 10.1016/j.cub.2019.12.052
PMCID: PMC7085240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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