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Article

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.

Cell reports - 28 Mar 2023

Chen Jia-Yun, Hug Clemens, Reyes José, Tian Chengzhe, Gerosa Luca, Fröhlich Fabian, Ponsioen Bas, Snippert Hugo J G, Spencer Sabrina L, Jambhekar Ashwini, Sorger Peter K, Lahav Galit

Abstract excerpt

Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senescing and others remaining proliferative. The causes of heterogeneity remain unclear. We studied the sources of heterogeneity in the responses of human epithelial cells to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36920903
DOI: 10.1016/j.celrep.2023.112252
PMCID: PMC10153468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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