Article

Ancestral resurrection reveals mechanisms of kinase regulatory evolution

2018-05-25

Abstract excerpt

Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. We used ancestral resurrection to uncover a mechanism underlying the evolution of kinase control within the ERK family of Mitogen Activated Protein Kinases (MAPKs). Kinase activities switched from high to low intrinsic autophosphorylation at the transition from the ancestors of ERKs1-5 and ERKs1-2. A...

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Literature Corpus work: cdae7458-8b06-57f2-a66c-1d43e4976307
DOI: 10.1101/331637

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