Article

Kinetic network model to explain gain-of-function mutations in ERK2 enzymes

2018-09-05

Abstract excerpt

<h4>ABSTRACT</h4> ERK2 is a kinase protein that belongs to a Ras/Raf/MEK/ERK signalling pathway, which is activated in response to a range of extracellular signals. Malfunctioning of this cascade leads to variety of serious diseases, including cancers. This is often caused by mutations in proteins belonging to the cascade, frequently leading to abnormally high activity of the cascade even in the absence of extern...

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Literature Corpus work: 91959223-4c6f-5c3b-a1ee-58f25622b17d
DOI: 10.1101/409482

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