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Article

Systems-level consequences of low RAF abundance for EGFR-ERK signaling.

Biophysical journal - 3 Feb 2026

Lee Sung Hyun, Myers Paul J, Mendrzycki Max C, Brown Kevin S, Loew Leslie M, Sorkin Alexander, Lazzara Matthew J

Abstract excerpt

RAFs initiate the cascade leading to activation of the extracellular signal-regulated kinases (ERKs). In a substantial fraction of cancer cells, RAFs are the least abundant pathway proteins between receptor tyrosine kinases and ERKs. In some cases, active RAF kinases are present at the plasma membrane at just hundreds of copies per cell, but the consequences of such limited RAF abundance are unclear. By...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41496453
DOI: 10.1016/j.bpj.2025.12.033
PMCID: PMC13093192

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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