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Article

A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways.

Oncogene - 5 Jul 2007

Kim D, Rath O, Kolch W, Cho K-H

Abstract excerpt

The Wnt and the extracellular signal regulated-kinase (ERK) pathways are both involved in the pathogenesis of various kinds of cancers. Recently, the existence of crosstalk between Wnt and ERK pathways was reported. Gathering all reported results, we have discovered a positive feedback loop embedded in the crosstalk between the Wnt and ERK pathways. We have developed a plausible model that represents the role of...

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Identifiers

PMID: 17237813
DOI: 10.1038/sj.onc.1210230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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